AMBIEN (Zolpidem) Dosage, Indication, Interactions, Side Effects
Zolpidem Tartrate Sublingual Tablets are indicated for the brief-term therapy of insomnia characterised by difficulties with sleep initiation see CLINICAL STUDIES (14). The effect of chronic daily administration of Zolpidem tartrate on oral tissue was evaluated in a 60-day open-label research in 60 insomniac patients. During short-term remedy (up to 10 nights) with Zolpidem tartrate at doses up to 10 mg, probably the most commonly noticed adverse reactions associated with the use of Zolpidem and seen at statistically important differences from placebo-treated patients were drowsiness (reported by 2% of Zolpidem patients), dizziness (1%), and diarrhea (1%). However, the cited figures present the doctor with a basis for estimating the relative contribution of drug and nondrug components to the incidence of unintended effects in the population studied. Zolpidem tartrate is contraindicated in sufferers with recognized hypersensitivity to Zolpidem.
Since sedative-hypnotics have the capability to depress respiratory drive, precautions needs to be taken if Zolpidem tartrate is prescribed to patients with compromised respiratory perform. Zolpidem tartrate sublingual tablets 10 mg are white, round tablets, flat-faced, bevel-edged with debossed P7” on one facet and plain on the other aspect. In a clinical trial, 7% of pediatric patients treated with Zolpidem tartrate zero.25 mg/kg taken at bedtime reported hallucinations, versus 0% handled with placebo see Use in Specific Populations (8.4). The following table was derived from a pool of eleven placebo-managed short-term U.S. efficacy trials involving Zolpidem in doses starting from 1.25 to 20 mg. The table is restricted to information from doses up to and together with 10 mg, the highest dose really useful for use. Coadministration of Zolpidem with other CNS depressants will increase the risk of CNS depression see Warnings and Precautions (5.1). Zolpidem tartrate was evaluated in healthy volunteers in single-dose interaction studies for several CNS drugs. Use of Rifampin in combination with Zolpidem may lower the efficacy of Zolpidem.
A examine involving haloperidol and Zolpidem revealed no effect of haloperidol on the pharmacokinetics or pharmacodynamics of Zolpidem. The dangers of respiratory despair needs to be thought of previous to prescribing Zolpidem tartrate in sufferers with respiratory impairment together with sleep apnea and myasthenia gravis. There have been reviews of withdrawal signs and symptoms following the fast dose lower or abrupt discontinuation of Zolpidem. The really helpful dose of cheap Ambien Zolpidem tartrate sublingual tablets in both of those patient populations is 5 mg once each day immediately before bedtime see Warnings and Precautions (5.1); Use in Specific Populations (8.5).